CTN committees meet to review protocols, monitor trials in progress, set priorities and debate policy. They also advise the Steering Committee to ensure that all trials maintain the highest scientific and ethical standards. Committee members are bound by strict rules of confidentiality. In addition to its standing committees below, the CTN has a number of ad hoc committees and working groups on topics such as ethics review, postdoctoral fellowships, international research, and cohort studies.

This expert group of scientists and people affected by HIV and other stakeholders serves as the CTN’s board of directors. Drawing on its broad range of expertise and knowledge of national and international trends, members consider the recommendations of other Network committees and set research priorities.

Experts in HIV clinical care, research design, biostatistics, ethics and law are among the members of DSMC, which monitors the safety and efficacy of trials in progress. The committee will also, occasionally, review preliminary analyses of trial results or new information and recommend changes in protocol or procedures, or the termination of a trial.

The CAC brings together a broadly representative group of nine people from across Canada who are living with HIV or representing organizations fighting the epidemic. This committee reviews all protocols and informed consents submitted to the Network and makes recommendations to the Steering Committee (SC). It also advises the Scientific Review Committee and trial investigators and informs the SC about the research priorities and concerns of HIV-positive Canadians.

Scientists, physicians and members of the HIV community are represented on this committee, which makes recommendations to the Steering Committee (SC). Members meet twice yearly and up to four times by teleconference to provide peer reviews of proposals submitted to the CTN. They evaluate the scientific merit of experimental therapies as well as the design of trial protocols to ensure that all CTN trials are relevant and based on sound methodology.

The EAC provides ongoing independent scientific advice and guidance to help ensure that the Network achieves its objectives and maximizes its research, training and knowledge translation outcomes. The EAC reviews the progress being made by the CTN on an annual basis in order to provide strategic advice to the CTN to help achieve objectives, overcome challenges and maximize outcomes. The EAC brings together five members with sufficient expertise to cover the breadth of the Network and includes a representative from CIHR.

The FC determines study funding allocations including unit funding as well as pilot/new concept funding, start-up funding, and principal investigator management support funding.

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