Research Projects:

  • Hepatic fibrosis progression in HIV-hepatitis C virus co-infection: The effect of iron-deficiency anemia among co-infected women
  • Hepatic fibrosis progression in HIV-hepatitis C virus co-infection: The effect of estrogen among co-infected women

Postdoc Year(s): 2016-2017, 2017-2018

Dr. Nadine Kronfli is a member of the CTN’s Prevention and Vulnerable Population’s Women’s Working Group, which is involved in the care of women living with HIV across Canada. She has “a longstanding interest in women living with HIV,” and says that “the best way to shape policy is by being at the forefront of clinical research.”

 

She has authored several abstracts using data from CTN 262: CHIWOS, the Canadian HIV Women’s Sexual and Reproductive Health Cohort Study, a longitudinal study that evaluates the success of women-centred HIV/AIDS services. Her CHIWOS research has primarily focused on the cascade of care, with particular attention to access to and retention in HIV care for Canadian women living with HIV. Her postdoctoral project, supervised by Dr. Marina Klein (McGill University Health Centre), will “put women at the forefront of research.”

Her projects will aim is to determine the role of iron-deficiency and estrogen-deficient states on the progression of liver fibrosis in HIV/hepatitis C co-infected Canadian women. Fibrosis progression remains an important topic of research even in the era of direct-acting antivirals. Many patients remain untreated due to the prohibitive cost of therapy and fibrosis restrictions. In addition, despite successful treatment, hepatic fibrosis may not regress completely. As such, Dr. Kronfli believes it is important to study other modifiable risk factors that may impact liver disease in the long-term, even among individuals who have been successfully treated. The hope is to then explore the role of iron supplementation and hormone replacement on the progression of liver fibrosis in interventional studies.

Dr. Kronfli completed a Bachelor of Science at McGill University, a Master of Public Health at the Yale School of Public Health, a Medical Doctorate at the University of Ottawa, and fellowships at both McMaster University (Internal Medicine and Infectious Diseases) and the Ontario HIV Treatment Network (HIV Care). She recently obtained her Diploma in Tropical Medicine and Hygiene from the Instituto de Medicina Tropical Alexander von Humboldt in Lima, Peru. At the University of Ottawa, she opted for the francophone stream of the medical program in order to be able to “serve in any corner of Canada as well as much of the world.” She begins her postdoctoral fellowship on July 1, 2016.