Shari Margolese
Chair, Community Advisory Committee (CAC)

Shari Margolese has been an advocate for the meaningful involvement of people living with HIV in all aspects of their care, including research, since shortly after her own HIV diagnosis in 1993.

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Her work as a community consultant and researcher includes various community based research projects focusing on the sexual and reproductive health of people living with HIV. Most recently, Shari co-authored the Canadian HIV Pregnancy Planning Guidelines which were published in the Canadian Journal of Obstetrics and Gynecology in June 2012. Additionally, Shari is an accomplished writer, speaker and facilitator with expertise in community development, disclosure and positive parenting.

Shari’s current research volunteer commitments include the Ontario HIV Treatment Network, Ontario Study Cohort Governance Committee, and the Community Advisory Committees of both the CTN and the Canadian Observational Cohort (CANOC). She also holds an appointment to the CIHR HIV Research Advisory Committee (CHARAC).

At the community level, Shari is a steering committee member of two important women’s health networks in Canada and internationally, Blueprint for Action on Women and Girls and HIV and the ATHENA network.

Shari is an inductee to the Ontario AIDS Network Honour Roll and received the Queen Elizabeth II Golden Jubilee Medal for her extraordinary commitment to the HIV community.

Anita R. Rachlis, MD, MEd, FRCPC
Chair, Postdoctoral Fellowship Adjudication Committee

Dr. Rachlis worked with the CTN since 1990 as a principal investigator. She is an investigator at the Sunnybrook Health Science Centre, and former Ontario regional director and Scientific Review Committee member.

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Dr. Rachlis has consistently promoted and participated in HIV clinical research in Ontario. Since 1986, Dr. Rachlis has served on numerous editorial, medical and advisory AIDS committees, including the Ontario AIDS Advisory Committee, the Ontario HIV Treatment Network and Health Canada’s Expert Advisory Committee on HIV Therapies. She was appointed to the Ministerial Council on HIV/AIDS in September 2003 and continues as an active member and council representative to the CIHR HIV/AIDS Research Advisory Committee.

She is also the head of the Division of Infectious Diseases and the medical director of the HIV Ambulatory Clinic at the Sunnybrook site, Sunnybrook and Women’s College Health Science Centre. Dr. Rachlis has been involved in a number of clinical trials involving antiretroviral agents and management of opportunistic infections.

Along with these affiliations and responsibilities, Dr. Rachlis is a professor in the Department of Medicine at the University of Toronto. She has a strong interest in medical education as the clerkship director of the undergraduate medical program at the University of Toronto, and earned her Master of Education from the Ontario Institute of Studies in Education in 1994. She served as a member of the executive council of the Canadian Association for HIV Research and chaired the Association’s 1994 conference in Toronto.

Stephen Shafran, MD, FRCPC
Chair, Data Safety Monitoring Committee

Dr. Stephen D. Shafran has lived in four different provinces. He is a native of Toronto and a graduate of the University of Toronto’s Faculty of Medicine. After completing his training in internal medicine in Toronto, he moved to Vancouver where he completed a fellowship in infectious diseases at UBC.

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In 1986, he accepted his first academic faculty appointment in the College of Medicine at the University of Saskatchewan in Saskatoon. In 1989, he moved to the University of Alberta in Edmonton, where he remains. In 1998, he was promoted to full professor and appointed as the director of the Division of Infectious Diseases. He was reappointed to that position in 2003.

Dr. Shafran has been involved in the care of persons living with HIV from the beginning of the epidemic in the pre-antiretroviral era. He continues to have a large HIV practice and also sees HIV patients at a federal penitentiary and a provincial prison in the Edmonton area. He participated in the early meetings that led to the creation of the CTN and has been the director of the Edmonton CTN satellite since its inception. Dr. Shafran has been involved in many CTN activities as a principal investigator, a co-investigator, a member of the Scientific Review Committee and, since 2003, as the chair of the Data Safety Monitoring Committee (formerly Safety and Efficacy Review Committee) and a member of the Steering Committee.

He remains recognized internationally for CTN clinical trial 010, which changed the treatment of disseminated MAC infection and led to a primary publication in the New England Journal of Medicine with several secondary publications. CTN 010 remains a model study for the CTN, as it was investigator generated, further developed with a CTN-funded workshop, supported by a partnership of public and private funding and open to all CTN sites willing to participate.

Along with his work for the CTN, Dr. Shafran also serves as a member of the Scientific Advisory Committee on HIV Therapies (Health Canada). As well, he remains active in the practice of infectious diseases outside of HIV medicine. He is the director of a division of 16 adult ID specialists and many support staff, and is a member of the Immigration Medical Advisory Committee (Citizenship and Immigration Canada). In addition, he represented the Association of Medical Microbiology and Infectious Diseases on the organizing committee of the 2004 Canadian Consensus Guidelines on the Management of Viral Hepatitis.

Lehana Thabane
Chair, Scientific Review Committee

Dr. Lehana Thabane has been a member of the CTN’s Scientific Review Committee (SRC) since 2006 and was appointed the chair of the SRC in 2008. He is also a member of the Steering and Finance Committees.

He is a Professor and Associate Chair of the Department of Clinical Epidemiology and Biostatistics, Associate Member of the Departments of Pediatrics and Anesthesia at McMaster University, Director of the Biostatistics Unit at St Joseph’s Healthcare, Hamilton, and Senior Scientist at the Population Health Research Institute, which is affiliated with both Hamilton Health Sciences and McMaster University.

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Dr. Thabane did his PhD in statistics (1994 -1998) at the University of Western Ontario, Canada and MSc in Statistics (1992-1993) at Sheffield University, England. He obtained his BSc (1986-1990) from the National University of Lesotho.

A research methodologist with research interests in the development and application of statistical methods health research, Dr. Thabane collaborates with researchers in HIV/AIDS, cardiology, internal medicine, nephrology, palliative care services, evidence-based medicine and health technology assessment. He provides statistical leadership in studies in various areas of population health research, clinical research and health services and outcomes research.

Dr. Thabane is also a Scientific Officer of the Randomized Clinical Trials Committee for the Canadian Institutes of Health Research (CIHR), and holds membership of the International Statistical Institute as well as the Statistical Society of Canada.

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